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BIBTEX RIS

Cytotoxicity of derivatives of oncocalyxone A from Auxemma oncocalyx Taub

2004; ARKAT USA, Inc.; Volume: 2004; Issue: 6 Linguagem: Inglês

10.3998/ark.5550190.0005.612

1551-7012

Cláudia Pessoa, Telma L. G. Lemos, Otília Deusdênia Loiola Pessoa, Manoel Odorico de Moraes, Denissa Vasconcellos, Letı́cia V. Costa-Lotufo, A. Leyva,

Marine Sponges and Natural Products

Oncocalyxone A (1) (rel-8α-hydroxy-5-hydroxymethyl-2-methoxy-8aβ-methyl-7,8,8a,9tetrahydro-1,4-anthracenedione) is a 1,4-anthracenedione that has been shown to be cytotoxic to human tumor cells and to be DNA reactive.Three derivatives of 1 obtained by chlorination (6chloro-oncocalyxone A, 2) and acetylation (11-O-acetyloncocalyxone A, 3; 8,11-Odiacetyloncocalyxone A, 4) were found to be less cytotoxic and less DNA reactive in human leukemia cells.These derivatives were less polar compounds with modifications that may have hindered binding of the compound to DNA.