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Endogenous Level and in Vitro Production of GHB in Blood from Healthy Humans, and the Interpretation of GHB Levels Detected in Antemortem Blood Samples

2005; Pharmaceutical Society of Japan; Volume: 51; Issue: 2 Linguagem: Inglês

10.1248/jhs.51.147

1347-5207

Noriaki Shima, Akihiro Miki, Tooru Kamata, Munehiro Katagi, Hitoshi Tsuchihashi,

Metabolomics and Mass Spectrometry Studies

The endogenous level of γ-hydroxybutyric acid (GHB) and the in vitro production of GHB in blood from healthy humans have been investigated. The endogenous GHB concentrations in aseptically collected whole blood samples ranged from 5 to 10 ng/ml, which were far below the previously-reported "endogenous" levels . Also, the levels of in vitro GHB production during storage for 16 months at 4°C were lower than 0.4 μg/ml, which were much lower than those in postmortem samples previously reported. Based on the results of this investigation, the authors concluded that an interpretative cutoff of 1.0 μg/ml would be appropriate for differentiating exogenous from endogenous GHB, if only limited to in-life blood specimens that were collected aseptically, stored at 4°C or lower, examined within two weeks, and excludes the possibility of GHB aciduria.