Amphiphilic Multi‐Arm Block Copolymer Based on Hyperbranched Polyester, Poly( L ‐lactide) and Poly(ethylene glycol) as a Drug Delivery Carrier
2008; Wiley; Volume: 9; Issue: 5 Linguagem: Inglês
10.1002/mabi.200800269
ISSN1616-5195
AutoresM. Prabaharan, Jamison Grailer, Srikanth Pilla, Douglas A. Steeber, Shaoqin Gong,
Tópico(s)Advanced Polymer Synthesis and Characterization
ResumoA novel type of biodegradable/biocompatible amphiphilic hyperbranched copolymer (H40-PLA-b-MPEG) was synthesized. Its micellar properties were studied by DLS, fluorescence spectroscopy and TEM. The drug release profile showed that the H40-PLA-b-MPEG micelles provide an initial burst release, followed by a sustained release of the entrapped hydrophobic model drug over a period of 4 to 58 h. The copolymer degraded hydrolytically within 6 weeks under physiological conditions. The MTT assay showed no obvious cytotoxicity against a human endothelial cell line at a concentration range of 0-400 microg x mL(-1). These results indicate that the H40-PLA-b-MPEG micelles have great potential as hydrophobic drug delivery carriers.
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