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Cellular Immunotherapy with Ex Vivo Expanded Cord Blood T Cells in a Humanized Mouse Model of EBV-associated Lymphoproliferative Disease

2015; Future Medicine; Volume: 7; Issue: 4 Linguagem: Inglês

10.2217/imt.15.2

1750-7448

Go Matsuda, Ken‐Ichi Imadome, Fuyuko Kawano, Masashi Mochizuki, Nakaba Ochiai, Tomohiro Morio, Norio Shimizu, Shigeyoshi Fujiwara,

Viral-associated cancers and disorders

Background: Donor lymphocyte infusion is not feasible in recipients of cord blood transplantation. Aim: We investigated whether infusion of T cells expanded from cord blood is effective in the treatment of model mice of Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD). Materials & methods: Humanized mice with reconstituted human immune system were prepared and LPD was induced by inoculating EBV intravenously. T cells were expanded from the same sample of cord blood as used for generation of humanized mice and infused to EBV-infected humanized mice. Results: Mice treated with expanded cord blood T cells lived significantly longer than control mice (p = 0.036). Conclusion: Infusion of T cells expanded from cord blood was effective in the treatment of model mice for EBV-associated LPD.