Subtype Selective Tetracycline Agonists and their Application for a Two‐Stage Regulatory System
2006; Wiley; Volume: 7; Issue: 9 Linguagem: Inglês
10.1002/cbic.200600226
ISSN1439-7633
AutoresChristian Berens, Susanne Lochner, Stefan Löber, Igor Usai, Andreas Schmidt, Lars Drueppel, Wolfgang Hillen, Peter Gmeiner,
Tópico(s)Cancer-related gene regulation
ResumoWe are in control. Rational-based structural modifications of tetracycline derivatives that can act as selective inducers of the transactivating proteins rtTA-1/2 and rtTA-D have been carried out. These modifications led to a novel two-stage regulatory system in which two separate genes can be regulated by using the selective inducers 9-dipropylaminodoxycycline (1) and doxycycline (dox). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2006/z600226_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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