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DEVELOPMENT AND EVALUATION OF NOVEL REPAGLINIDE BIO STRIPS FOR TRANSLABIAL DELIVERY

2013; Volume: 4; Issue: 5 Linguagem: Inglês

10.7897/2230-8407.04540

2230-8407

N. V. Satheesh Madhav, Abhay Pratap Yadav,

Botanical Research and Chemistry

The aim of this study was to explore the potentiality of lip skin as a novelistic Translabial drug delivery platform due to its unique histology and by formulating drug loaded bio lip strips using novel bio-excipients which was isolated from the seeds of zea mays by simplified economical process and purified by hot dialysis method.Repaglinide loaded bio-lip strips were formulated by using zea mays bio-material as a strip former and dextrose as a flexicizer.The formulated strips were subjected for various evaluation parameters like thickness, folding endurance and in-vitro and In-vivo drug release.Present study revealed that the biopolymer possessing promising strip ability.The Repaglinide release was extended over a period of 24 hrs and by fitting the drug release data into zero order, first order and Higuchi model, it was concluded that drug release from strips followed Higuchi model and the mechanism of the drug release was diffusion and anomalous type.On the basis of above parameters and used concentration of biopolymer in the formulation, F2 was selected as the best formulation.The in vitro and in-vivo studies have shown the potential of the Repaglinide loaded bio strip for sustained delivery through Translabial route.