T cell receptors in rheumatoid arthritis
1995; Wiley; Volume: 38; Issue: 5 Linguagem: Inglês
10.1002/art.1780380502
ISSN1529-0131
AutoresLinda Struyk, Gail E. Hawes, M Chatila, Ferdinand C. Breedveld, James T. Kurnick, Peter J. van den Elsen,
Tópico(s)Rheumatoid Arthritis Research and Therapies
ResumoArthritis & RheumatismVolume 38, Issue 5 p. 577-589 ReviewFree to Read T cell receptors in rheumatoid arthritis Linda Struyk MD, Linda Struyk MD University Hospital Leiden, Leiden, The NetherlandsSearch for more papers by this authorGail E. Hawes MD, Gail E. Hawes MD University Hospital Leiden, Leiden, The NetherlandsSearch for more papers by this authorMay K. Chatila MD, May K. Chatila MD Harvard Medical School and Massachusetts General Hospital, Charlestown, MassachusettsSearch for more papers by this authorFerdinand C. Breedveld MD, Ferdinand C. Breedveld MD University Hospital Leiden, Leiden, The NetherlandsSearch for more papers by this authorJames T. Kurnick MD, James T. Kurnick MD Harvard Medical School and Massachusetts General Hospital, Charlestown, MassachusettsSearch for more papers by this authorPeter J. Van Den Elsen PhD, Corresponding Author Peter J. Van Den Elsen PhD University Hospital Leiden, Leiden, The NetherlandsDepartment of Immunohematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300 RC Leiden, The NetherlandsSearch for more papers by this author Linda Struyk MD, Linda Struyk MD University Hospital Leiden, Leiden, The NetherlandsSearch for more papers by this authorGail E. Hawes MD, Gail E. Hawes MD University Hospital Leiden, Leiden, The NetherlandsSearch for more papers by this authorMay K. Chatila MD, May K. Chatila MD Harvard Medical School and Massachusetts General Hospital, Charlestown, MassachusettsSearch for more papers by this authorFerdinand C. Breedveld MD, Ferdinand C. Breedveld MD University Hospital Leiden, Leiden, The NetherlandsSearch for more papers by this authorJames T. Kurnick MD, James T. Kurnick MD Harvard Medical School and Massachusetts General Hospital, Charlestown, MassachusettsSearch for more papers by this authorPeter J. Van Den Elsen PhD, Corresponding Author Peter J. Van Den Elsen PhD University Hospital Leiden, Leiden, The NetherlandsDepartment of Immunohematology and Blood Bank, University Hospital Leiden, P. O. Box 9600, 2300 RC Leiden, The NetherlandsSearch for more papers by this author First published: May 1995 https://doi.org/10.1002/art.1780380502Citations: 73AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Duke O, Panayi GS, Janossy G, Poultier LW: An immunohistological analysis of lymphocyte subpopulations and their microenvironment in the synovial membranes of patients with rheumatoid arthritis using monoclonal antibodies. Clin Exp Immunol 49: 22–30, 1982 CASPubMedWeb of Science®Google Scholar 2 Forre O, Thoen J, Lea T, Dobloug JH, Mellbye OJ, Natvig JB, Pahle J, Solheim BG: In situ characterization of mononuclear cells in rheumatoid arthritis, using monoclonal antibodies. Scand J Immunol 16: 315–319, 1982 10.1111/j.1365-3083.1982.tb00729.x CASPubMedWeb of Science®Google Scholar 3 Janossy G, Duke O, Poultier LW, Panayi G, Bofill M, Goldstein G: Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet II: 839–842, 1981 10.1016/S0140-6736(81)91107-7 CASGoogle Scholar 4 Poulter LW, Duke O, Panayi GS, Hobbs S, Raftery MJ, Janossy G: Activated T lymphocytes of the synovial membrane in rheumatoid arthritis and other arthropathies. Scand J Immunol 22: 683–690, 1988 10.1111/j.1365-3083.1985.tb01931.x PubMedWeb of Science®Google Scholar 5 Davis MM: T cell receptor gene diversity and selection. Annu Rev Biochem 59: 475–496, 1990 10.1146/annurev.bi.59.070190.002355 CASPubMedWeb of Science®Google Scholar 6 Epplen JT, Chluba J, Hardt C, Hinkkanan A, Steimle V, Stockinger H: Mammalian T lymphocyte receptor genes: genetic and non-genetic potential to generate variability. Hum Genet 75: 300–310, 1987 10.1007/BF00284099 CASPubMedWeb of Science®Google Scholar 7 Davis MM, Bjorkman PJ: T cell antigen receptor genes and T cell recognition. Nature 334: 395–401, 1988 10.1038/334395a0 CASPubMedWeb of Science®Google Scholar 8 Toyonaga B, Mak TW: Genes of the T-cell antigen receptor in normal and malignant T cells. Annu Rev Immunol 5: 585–620, 1987 10.1146/annurev.iy.05.040187.003101 CASPubMedWeb of Science®Google Scholar 9 Wilson RK, Lai E, Concannon P, Barth RK, Hood LE: Structure, organization and polymorphism of murine and human T-cell receptor α and β chain gene families. Immunol Rev 101: 149–172, 1988 10.1111/j.1600-065X.1988.tb00736.x CASPubMedWeb of Science®Google Scholar 10 Chothia C, Boswell DR, Lesk AM: The outline structure of the T-cell αβ receptor. EMBO J 7: 3745–3755, 1988 10.1002/j.1460-2075.1988.tb03258.x CASPubMedWeb of Science®Google Scholar 11 Claverie JM, Prochnika-Chalufour A, Bougueleret L: Implications of Fab-like structure for the T-cell receptor. Immunol Today 10: 10–14, 1989 10.1016/0167-5699(89)90058-3 CASPubMedWeb of Science®Google Scholar 12 Hong SC, Chelouche A, Lin R, Shaywitz D, Braunstein NS, Glimcher L, Janeway CA Jr: An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain. Cell 69: 999–1009, 1992 10.1016/0092-8674(92)90618-M CASPubMedWeb of Science®Google Scholar 13 Jores R, Alzari PM, Meo T: Resolution of hypervariable regions in T-ce11 receptor β chains by a modified Wu-Kabat index of amino acid diversity. Proc Natl Acad Sci U S A 87: 9138–9142, 1990 10.1073/pnas.87.23.9138 CASPubMedWeb of Science®Google Scholar 14 Pullen AM, Wade T, Marrack P, Kappler JW: Identification of the region of T cell receptor β chain that interacts with the self-superantigen Mls-1a. Cell 61: 1365–1374, 1990 10.1016/0092-8674(90)90700-O CASPubMedWeb of Science®Google Scholar 15 Patten PA, Rock EP, Sonoda T, Fazekas de St. Groth B, Jorgensen JL, Davis MM: Transfer of putative complementarity-determining region loops of T cell receptor V domains confers toxin reactivity but not peptide/MHC specificity. J Immunol 150: 2281–2294, 1993 10.4049/jimmunol.150.6.2281 CASPubMedWeb of Science®Google Scholar 16 Engel I, Hedrick SM: Site-directed mutations in the VDJ junctional region of a T cell receptor β chain cause changes in antigenic peptide recognition. Cell 54: 473–484, 1988 10.1016/0092-8674(88)90068-2 CASPubMedWeb of Science®Google Scholar 17 Jorgensen JL, Esser U, Fazekas de St. Groth B, Reay PA, Davis MM: Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature 355: 224–230, 1992 10.1038/355224a0 CASPubMedWeb of Science®Google Scholar 18 Sorger SB, Paterson Y, Fink PJ, Hedrick SM: T cell receptor junctional regions and the MHC molecule affect recognition of antigenic peptides by T cell clones. J Immunol 144: 1127–1135, 1990 CASPubMedWeb of Science®Google Scholar 19 Danska JS, Livingstone AM, Paragas V, Ishihara T, Fathman CG: The presumptive CDR3 regions of both T cell receptor α and β chains determine T cell specificity for myoglobin peptides. J Exp Med 172: 27–33, 1990 10.1084/jem.172.1.27 CASPubMedWeb of Science®Google Scholar 20 Acha-Orbea H, Mitchell DJ, Timmermann L, Wraith DC, Tausch GS, Waldor MK, Zamvil SS, McDevitt HO, Steinman L: Limited heterogeneity of T cell receptors from T lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54: 263–273, 1988 10.1016/0092-8674(88)90558-2 PubMedWeb of Science®Google Scholar 21 Bowness P, Moss PHA, Rowland-Jones S, Bell JI, McMichael AJ: Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex I-restricted responses. J Immunol 23: 1417–1421, 1993 10.1002/eji.1830230702 CASPubMedWeb of Science®Google Scholar 22 Gold DP, Offner H, Sun D, Wiley S, Vandenbark AA, Wilson DB: Analysis of T cell receptor β chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3. J Exp Med 174: 1467–1476, 1991 10.1084/jem.174.6.1467 CASPubMedWeb of Science®Google Scholar 23 Hedrick SM, Engel I, McElligott DL, Fink PJ, Hsu M, Hansburg D, Matis LA: Selection of amino acid sequences in the beta chain of T cell antigen receptor. Science 239: 1541–1544, 1988 10.1126/science.2832942 CASPubMedWeb of Science®Google Scholar 24 Moss PAH, Moots RJ, Rosenberg WMC, Rowland-Jones SJ, Bodmer HC, McMichael AJ, Bell JI: Extensive conservation of α and β chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. Proc Natl Acad Sci U S A 88: 8987–8990, 1991 10.1073/pnas.88.20.8987 CASPubMedWeb of Science®Google Scholar 25 Van Schooten WCA, Long Ko J, van der Stoep N, Haanen JBAG, Pickering L, de Vries RRP, van den Elsen PJ: T cell receptor β-chain gene usage in the T cell recognition of Myco-bacterium leprae antigens in one tuberculoid leprosy patient. Proc Natl Acad Sci U S A 89: 11244–11248, 1992 10.1073/pnas.89.23.11244 CASPubMedWeb of Science®Google Scholar 26 Cooper SM, Dier DL, Roessner KD, Budd RC, Nicklas JA: Diversity of rheumatoid synovial tissue T cells by T cell receptor analysis: oligoclonal expansion in interleukin-2-responsive cells. Arthritis Rheum 34: 537–546, 1991 10.1002/art.1780340505 CASPubMedWeb of Science®Google Scholar 27 Van Laar JM, Miltenburg AMM, Verdonk MJA, Daha MR, de Vries RRP, van den Elsen PJ, Breedveld FC: Lack of T cell oligoclonality in enzyme-digested synovial tissue and in synovial fluid in most patients with rheumatoid arthritis. Clin Exp Immunol 83: 352–358, 1991 10.1111/j.1365-2249.1991.tb05642.x CASPubMedWeb of Science®Google Scholar 28 Van Laar JM, Miltenburg AMM, Verdonk MJA, Daha MR, de Vries RRP, van den Elsen PJ, Breedveld FC: T-cell receptor β-chain gene rearrangements of T cell populations expanded from multiple sites of synovial tissue obtained from a patient with rheumatoid arthritis. Scand J Immunol 35: 187–194, 1992 10.1111/j.1365-3083.1992.tb02849.x CASPubMedWeb of Science®Google Scholar 29 Miltenburg AMM, van Laar JM, Daha MR, de Vries RRP, van den Elsen PJ, Breedveld FC: Dominant T-cell receptor β-chain gene rearrangements indicate clonal expansion in the rheumatoid joint. Scand J Immunol 31: 121–125, 1990 10.1111/j.1365-3083.1990.tb02750.x CASPubMedWeb of Science®Google Scholar 30 Savill CM, Delves PJ, Kioussis D, Walker P, Lydyard PM, Colaco B, Shipley M, Roitt IM: A minority of patients with rheumatoid arthritis show a dominant rearrangement of T-cell receptor β chain genes in synovial lymphocytes. Scand J Immunol 25: 629–635, 1987 10.1111/j.1365-3083.1987.tb01089.x CASPubMedWeb of Science®Google Scholar 31 Stamenkovic I, Stegagno M, Wright KA, Amento EP, Colvin RB, Duquesnoy RJ, Kurnick JT: Clonal dominance among T-lymphocyte infiltrates in arthritis. Proc Natl Acad Sci U S A 85: 1179–1183, 1988 10.1073/pnas.85.4.1179 PubMedWeb of Science®Google Scholar 32 Keystone EC, Minden M, Klock R, Poplonski L, Zalcberg J, Takadera T, Mak TW: Structure of T cell antigen receptor β chain in synovial fluid cells from patients with rheumatoid arthritis. Arthritis Rheum 31: 1555–1557, 1988 10.1002/art.1780311213 CASPubMedWeb of Science®Google Scholar 33 Stamenkovic I, Stegagno M, Wright KA, Krane SM, Amento EP, Colvin RB, Duquesnoy RJ, Kurnick JT: T lymphocyte infiltrates in inflammatory synovia are oligoclonal. Transpl Proc 20: 315–319, 1988 CASPubMedWeb of Science®Google Scholar 34 Duby AD, Sinclair AK, Osborne-Lawrence SL, Zeldes W, Kan L, Fox DA: Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis. Proc Natl Acad Sci U S A 86: 6206–6210, 1989 10.1073/pnas.86.16.6206 PubMedWeb of Science®Google Scholar 35 Grunewald J, Shankar NR, Wizgell H, Janson CH: An analysis of α/β TCR V gene expression in the human thymus. Int Immunol 3: 699–702, 1991 10.1093/intimm/3.7.699 CASPubMedWeb of Science®Google Scholar 36 Kronenberg M, Siu G, Hood LE, Shastri N: The molecular genetics of the T-cell receptor and T-cell antigen recognition. Annu Rev Immunol 4: 529–591, 1986 10.1146/annurev.iy.04.040186.002525 CASPubMedWeb of Science®Google Scholar 37 Moss PAH, Rosenberg WMC, Bell JI: The human T cell receptor in health and disease. Annu Rev Immunol 10: 71–96, 1992 10.1146/annurev.iy.10.040192.000443 CASPubMedWeb of Science®Google Scholar 38 Raaphorst FM, Kaijzel EL, van Tol MJD, Vossen JM, van den Elsen PJ: Non-random employment of Vβ6 and Jβ gene elements and conserved amino acid usage in CDR3 regions of human fetal and adult TCR β chain rearrangements. Int Immunol 6: 1–9, 1993 10.1093/intimm/6.1.1 Web of Science®Google Scholar 39 Robinson MA: Usage of human T-cell receptor Vβ, Jβ, Cβ and Vα gene segments is not proportional to gene number. Hum Immunol 35: 60–67, 1992 10.1016/0198-8859(92)90095-5 CASPubMedWeb of Science®Google Scholar 40 Rosenberg WMC, Moss PAH, Bell JI: Variation in human T cell receptor Vβ and Jβ repertoire: analysis using anchor polymerase chain reaction. Eur J Immunol 22: 541–549, 1992 10.1002/eji.1830220237 CASPubMedWeb of Science®Google Scholar 41 Kohsaka H, Taniguchi A, Chen PP, Ollier WER, Carson DA: The expressed T cell receptor V gene repertoire of rheumatoid arthritis monozygotic twins: rapid analysis by anchored polymerase chain reactions and enzyme-linked immunosorbent assay. Eur J Immunol 23: 1895–1901, 1993 10.1002/eji.1830230825 CASPubMedWeb of Science®Google Scholar 42 Krawinkel U, Pluschke G: T cell receptor variable region repertoire in lymphocytes from rheumatoid arthritis patients. Immunobiology 185: 483–491, 1992 10.1016/S0171-2985(11)80090-2 CASPubMedWeb of Science®Google Scholar 43 Pluschke G, Ricken G, Taube H, Kroninger S, Melchers I, Hartmut Peter H, Eichmann K, Krawinkel U: Biased T cell receptor Vα region repertoire in the synovial fluid of rheumatoid arthritis patients. Eur J Immunol 21: 2749–2754, 1991 10.1002/eji.1830211115 CASPubMedWeb of Science®Google Scholar 44 Uematsu Y, Wege H, Straus A, Ott M, Bannwarth W, Lanchbury J, Panayi G, Steinmetz M: The T-cell receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal. Proc Natl Acad Sci U S A 88: 8534–8538, 1991 10.1073/pnas.88.19.8534 CASPubMedWeb of Science®Google Scholar 45 Bucht A, Oksenberg JR, Lindblad S, Grönberg A, Steinman L, Klareskog L: Characterization of T-cell receptor αβ repertoire in synovial tissue from different temporal phases of rheumatoid arthritis. Scand J Immunol 35: 159–165, 1992 10.1111/j.1365-3083.1992.tb02846.x CASPubMedWeb of Science®Google Scholar 46 Davey PM, Munkirs DD: Patterns of T-cell receptor variable β gene expression by synovial fluid and peripheral blood T-cells in rheumatoid arthritis. Clin Immunol Immunopathol 68: 79–87, 1993 10.1006/clin.1993.1099 CASPubMedWeb of Science®Google Scholar 47 Dedeoglu F, Kaymaz H, Seaver N, Schluter SF, Yocum DE, Marchalonis JJ: Lack of preferential Vβ usage in synovial T cells of rheumatoid arthritis patients. Immunol Res 12: 12–20, 1993 10.1007/BF02918365 CASPubMedWeb of Science®Google Scholar 48 Howell MD, Diveley JP, Lundeen KA, Esty A, Winters ST, Carlo DJ, Brostoff SW: Limited T-cell receptor β-chain heterogeneity among interleukin 2 receptor-positive synovial T-cells suggests a role for superantigen in rheumatoid arthritis. Proc Natl Acad Sci U S A 88: 10921–10925, 1991 10.1073/pnas.88.23.10921 CASPubMedWeb of Science®Google Scholar 49 Jenkins RN, Nikaein A, Zimmermann A, Meek K, Lipsky PE: T cell receptor Vβ gene bias in rheumatoid arthritis. J Clin Invest 92: 2688–2701, 1993 10.1172/JCI116886 CASPubMedWeb of Science®Google Scholar 50 Lunardi C, Marguerie C, So AK: An altered repertoire of T cell receptor V gene expression by rheumatoid synovial fluid T lymphocytes. Clin Exp Immunol 90: 440–446, 1992 10.1111/j.1365-2249.1992.tb05865.x CASPubMedWeb of Science®Google Scholar 51 Maruyama T, Saito I, Miyake S, Hashimoto H, Sato K, Yagita H, Okumura K, Miyasaka N: A possible role of two hydrophobic amino acids in antigen recognition by synovial T cells in rheumatoid arthritis. Eur J Immunol 23: 2059–2065, 1993 10.1002/eji.1830230903 CASPubMedWeb of Science®Google Scholar 52 Olive C, Gatenby PA, Serjeantson SW: Analysis of T cell receptor Vα and Vβ gene usage in synovia of patients with rheumatoid arthritis. Immunol Cell Biol 69: 349–354, 1991 10.1038/icb.1991.50 PubMedWeb of Science®Google Scholar 53 Paliard X, West SG, Lafferty JA, Clements JR, Kappler JW, Marrack P, Kotzin BL: Evidence for the effects of a superantigen in rheumatoid arthritis. Science 253: 325–329, 1991 10.1126/science.1857971 CASPubMedWeb of Science®Google Scholar 54 Pluschke G, Ginter A, Taube H, Melchers I, Peter HH, Krawinkel U: Analysis of T cell receptor Vβ regions expressed by rheumatoid synovial T lymphocytes. Immunobiology 188: 330–339, 1993 10.1016/S0171-2985(11)80217-2 CASPubMedWeb of Science®Google Scholar 55 Sioud M, Kjeldsen-Kragh J, Quayle AJ, Wiker HG, Sorskaar D, Natvig JB, Forre O: Immune responses to 18.6- and 30-kDa mycobacterial antigens in rheumatoid patients, and Vβ usage by specific synovial T-cell lines and fresh T cells. Scand J Immunol 34: 803–812, 1991 10.1111/j.1365-3083.1991.tb01605.x CASPubMedWeb of Science®Google Scholar 56 Sottini A, Imberti L, Gorla R, Cattaneo R, Primi D: Restricted expression of T-cell receptor Vβ but not Vα genes in rheumatoid arthritis. Eur J Immunol 21: 461–466, 1991 10.1002/eji.1830210231 CASPubMedWeb of Science®Google Scholar 57 Struyk L, Kurnick JT, Hawes GE, van Laar JM, Schipper R, Oksenberg JR, Steinman L, de Vries RRP, Breedveld FC, van den Elsen PJ: T-cell receptor V-gene usage in synovial fluid lymphocytes of patients with chronic arthritis. Hum Immunol 37: 237–251, 1993 10.1016/0198-8859(93)90507-W CASPubMedWeb of Science®Google Scholar 58 Struyk L, Hawes GE, Dolhain RJEM, Scherpenzeel A, Godthelp B, Breedveld FC, van den Elsen PJ: Evidence for selective in vivo expansion of synovial tissue infiltrating CD4+CD45RO+ T-lymphocytes on the basis of CDR3 diversity. Int Immunol 6: 897–907, 1994 10.1093/intimm/6.6.897 CASPubMedWeb of Science®Google Scholar 59 Williams WV, Kieber-Emmons T, Fang Q, von Feldt J, Wang B, Ramanujam T, Weiner DB: Conserved motifs in rheumatoid arthritis synovial tissue T-cell receptor β chains. DNA Cell Biol 12: 425–434, 1993 10.1089/dna.1993.12.425 CASPubMedWeb of Science®Google Scholar 60 Sottini A, Imberti L, Bettinardi A, Mazza C, Gorla R, Primi D: Selection of T lymphocytes in two rheumatoid arthritis patients defines different T-cell receptor Vβ repertoires in CD4+ and CD8+ T-cell subsets. J Autoimmunity 6: 621–637, 1993 10.1006/jaut.1993.1051 CASPubMedWeb of Science®Google Scholar 61 Brennan FM, Allard S, Londei M, Savill C, Boylston A, Carrel S, Maini RN: Heterogeneity of T cell receptor idiotypes in rheumatoid arthritis. Clin Exp Immunol 73: 417–423, 1988 PubMedWeb of Science®Google Scholar 62 Bröker BM, Korthäuer U, Heppt P, Weseloh G, de la Camp R, Krozcek RA, Emmrich F: Biased T cell receptor V gene usage in rheumatoid arthritis: oligoclonal expansion of T cells expressing Vα2 genes in synovial fluid but not in peripheral blood. Arthritis Rheum 36: 1234–1243, 1993 10.1002/art.1780360908 CASPubMedWeb of Science®Google Scholar 63 Der Simonian H, Sugita M, Glass DN, Maier AL, Weinblatt ME, Rème T, Brenner MB: Clonal Vα12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients. J Exp Med 177: 1623–1631, 1993 10.1084/jem.177.6.1623 CASPubMedWeb of Science®Google Scholar 64 Gudmundsson S, Rönnelid J, Karlsson-Parra A, Lysholm J, Gudbjörnsson B, Widenfalk B, Janson CH, Klareskog L: T-cell receptor V-gene usage in synovial fluid and synovial tissue from RA patients. Scand J Immunol 36: 681–688, 1992 10.1111/j.1365-3083.1992.tb03128.x CASPubMedWeb of Science®Google Scholar 65 De Keyser F, Benoit D, Elewaut D, Leroy B, Malfait AM, Verbruggen G, Veys EM: T-cell receptor expression in patients with rheumatic disease. Prog Histochem Cytochem 26: 218–222, 1992 10.1016/S0079-6336(11)80098-7 CASPubMedGoogle Scholar 66 Sioud M, Kjeldsen-Kragh J, Suleyman S, Vinje O, Natvig JB, Forre O: Limited heterogeneity of T cell receptor variable region gene usage in juvenile arthritis synovial T cells. Eur J Immunol 22: 2413–2418, 1992 10.1002/eji.1830220934 CASPubMedWeb of Science®Google Scholar 67 Grom AA, Thompson SD, Luyrink L, Passo M, Choi E, Glass DN: Dominant T-cell-receptor β chain variable region Vβ14+ clones in juvenile rheumatoid arthritis. Proc Natl Acad Sci U S A 90: 11104–11108, 1993 10.1073/pnas.90.23.11104 CASPubMedWeb of Science®Google Scholar 68 Burns FR, Li X, Shen N, Offner H, Chou YK, Vandenbark AA, Heber-Katz E: Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα and Vβ chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J Exp Med 169: 27–39, 1989 10.1084/jem.169.1.27 CASPubMedWeb of Science®Google Scholar 69 Chubla J, Steeg C, Becker A, Wekerle H, Epplen JT: T cell receptor β chain usage in myelin basic protein-specific rat T lymphocytes. Eur J Immunol 19: 279–284, 1989 10.1002/eji.1830190210 PubMedWeb of Science®Google Scholar 70 Zamvil SS, Mitchell DJ, Lee NE, Moore AC, Waldor MK, Sakai K, Rothbard JB, McDevitt HO, Steinman L, Acha-Orbea H: Predominant expression of a T cell receptor Vβ gene family in autoimmune encephalomyelitis. J Exp Med 167: 1586–1596, 1988 10.1084/jem.167.5.1586 CASPubMedWeb of Science®Google Scholar 71 Gold DP, Vainiene M, Celnik B, Wiley S, Gibbs C, Hashim GA, Vandenbark AA, Offner H: Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. II. Biased T cell receptor Vβ expression predominates in spinal cord infiltrating T cells. J Immunol 148: 1712–1717, 1992 CASPubMedWeb of Science®Google Scholar 72 Offner H, Vainiene M, Gold DP, Celink B, Wang R, Hashim GA, Vandenbark AA: Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. I. T cell receptor peptide regulation of T cell clones expressing cross-reactive Vβ genes. J Immunol 148: 1706–1711, 1992 CASPubMedWeb of Science®Google Scholar 73 Struyk L, Hawes GE, Haanen JBAG, de Vries RRP, van der Elsen P: Clonal dominance and selection for similar complementarity determining region 3 motifs among T lymphocytes responding to the HLA-DR3 associated Mycobacterium leprae heat shock protein 65 kD peptide 3–13. Submitted for publication Google Scholar 74 Van Boxel-Dezaire A, Van Eggermond MCJA, Herwood J, Peynenburg A, Schipper R, Sanal Ö, Ersoy F, van Tol MJD, Vossen JM, van den Elsen PJ: Impact of the major histocompatibility complex class II deficiency on the CDR3 amino acid profiles of TCRBV6 rearrangements transcribed by peripheral CD4+CD8– T cells. Submitted for publication Google Scholar 75 Hingorani R, Choi IH, Akolkar P, Gulwani-Akolkar B, Pergolizzi R, Silver J, Gregersen PK: Clonal predominancé of T cell receptors within the CD8+CD45RO+ subset in normal human subjects. J Immunol 151: 5762–5769, 1993 CASPubMedWeb of Science®Google Scholar 76 Posnett DN, Sinha R, Kabak S, Russo C: Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy". J Exp Med 179: 609–618, 1994 10.1084/jem.179.2.609 CASPubMedWeb of Science®Google Scholar Citing Literature Volume38, Issue5May 1995Pages 577-589 ReferencesRelatedInformation
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