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Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8 + T-Cell Epitopes

2007; American Society for Microbiology; Volume: 81; Issue: 7 Linguagem: Inglês

10.1128/jvi.02689-06

1098-5514

Isobella Honeyborne, Andrew J. Prendergast, Florencia Pereyra, Alasdair Leslie, Hayley Crawford, Rebecca P. Payne, Shabashini Reddy, Karen Bishop, Eshia Moodley, K. Narayanan Nair, Mary van der Stok, Noel McCarthy, Christine Rousseau, Marylyn M. Addo, James I. Mullins, Christian Brander, Photini Kiepiela, Bruce D. Walker, Philip Goulder,

T-cell and B-cell Immunology

To better understand relationships between CD8+ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three Gag epitopes. These B*13-restricted epitopes contribute to a broad Gag-specific CD8+ response that is associated with the control of viremia. These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia.