Insulin-like growth factor-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes
2005; Oxford University Press; Volume: 68; Issue: 3 Linguagem: Inglês
10.1016/j.cardiores.2005.06.028
ISSN1755-3245
AutoresKou‐Gi Shyu, W.H. Ko, Wei‐Shiung Yang, Bo Wang, P Kuan,
Tópico(s)Muscle activation and electromyography studies
ResumoObjectives: Myostatin, a negative regulator of muscle growth, is increased in hypertrophied and infarcted heart. However, the mechanism of regulation is not known. Mechanical stress is an important regulatory factor for cardiomyocyte growth. The aim of the study was to investigate the effect of cyclic stretch on the expression of myostatin gene in cardiomyocytes.
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