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COMPARISON OF THE BEHAVIOUR OF A SOLUBLE AND A MEMBRANE‐BOUND ENZYME IN TRANSECTED PERIPHERAL NERVES

1969; Wiley; Volume: 16; Issue: 6 Linguagem: Inglês

10.1111/j.1471-4159.1969.tb08981.x

1471-4159

J Skangiel-Kramska, S Niemierko, Liliana Lubińska,

Retinoids in leukemia and cellular processes

Abstract— Phosphoglucoisomerase (PGI), a soluble enzyme, and AChE, a membrane‐bound enzyme were studied in transected peroneal nerves of dog and in isolated segments of these nerves. Although activities of both enzymes increased at the ends of transected nerves, marked differences in their behaviour were observed. The increment in AChE activity was much sharper than that of PGI and continued to grow with time whereas the increase in PGI developed fully within the initial hours after transection and did not change thereafter. In an isolated nerve segment AChE accumulated at both ends with a concomitant decrease in the middle part, whereas changes in PGI activity appeared only in the terminal parts, the rest of the nerve remaining at the normal level. The terminal increase of PGI did not, contrary to that of AChE, depend on the length of the isolated segment. The changes in PGI activity may be features of a local peritraumatic reaction whereas those of AChE indicate involvement of the whole segment along which the enzyme containing organelles are transported.