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Constitutional and Environmental Factors Related to Serum Lipid and Lipoprotein Levels

1967; American College of Physicians; Volume: 66; Issue: 3 Linguagem: Inglês

10.7326/0003-4819-66-3-540

1539-3704

William R. Harlan,

Lipoproteins and Cardiovascular Health

Article1 March 1967Constitutional and Environmental Factors Related to Serum Lipid and Lipoprotein LevelsWILLIAM R. HARLAN JR., M.D., ALBERT OBERMAN, M.D., ROBERT E. MITCHELL, M.D., ASHTON GRAYBIEL, M.D.WILLIAM R. HARLAN JR., M.D., ALBERT OBERMAN, M.D., ROBERT E. MITCHELL, M.D., ASHTON GRAYBIEL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-3-540 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite the important association between elevated plasma lipids and the development of coronary heart disease, there is a surprising lack of information relating plasma lipid levels to specific genetic and environmental factors. The striking differences in plasma lipids among populations with environments that are widely divergent are readily explained by dietary and other ecological differences. However, these factors are relatively homogenous within population groups, particularly in this country, and individual differences in lipid levels cannot be explained by ecological differences. Constitutional and environmental factors are primarily responsible for these differences (1-3), but few of these have been identified and quantified...References1. ADLERSBERGSCHAEFER DLE: The interplay of heredity and environment in the regulation of circulating lipids and in atherogenesis (editorial). Amer. J. Med. 26: 1, 1959. CrossrefMedlineGoogle Scholar2. SCHAEFERADLERSBERGSTEINBERG LEDAG: Heredity, environment, and serum cholesterol: a study of 201 healthy families. Circulation 17: 537, 1958. CrossrefMedlineGoogle Scholar3. DEUTSCHEREPSTEINKJELSBERG SFHMO: Familial aggregation of factors associated with coronary artery disease. Circulation 33: 911, 1966. CrossrefMedlineGoogle Scholar4. FREDRICKSONLEES DSRS: A system for phenotyping hyperlipoproteinemia (editorial). 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OSTRANDERFRANCISHAYNERKJELSBERGEPSTEIN LDTNSMOFH: The relationship of cardiovascular disease to hyperglycemia. Ann. Intern. Med. 62: 1188, 1965. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM R. HARLANJR., M.D.; ALBERT OBERMAN, M.D.; ROBERT E. MITCHELL, M.D.; ASHTON GRAYBIEL, M.D.Affiliations: Pensacola, FloridaFrom the U. S. Naval Aerospace Medical Institute, Pensacola, Fla.This research was supported in part by order R-136, the National Aeronautics and Space Administration, Washington, D. C.Dr. Oberman was supported by fellowship 1-F3-HE-33, the U. S. Public Health Service, U. S. Navy, Washington, D. C., and Dr. Harlan is a Markle Scholar in Academic Medicine.Requests for reprints should be addressed to William R. Harlan, Jr., M.D., Box 155, Medical College of Virginia, Richmond, Va. 23219. 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BIERMAN, M.D., F.A.C.P., DANIEL PORTE JR., M.D.SPECIAL ARTICLE 1 March 1967Volume 66, Issue 3Page: 540-555KeywordsBlood plasmaCholesterolCoronary heart diseaseFellowshipsGenetic diseasesHyperlipidemiaLipidsLipoproteinsMedical servicesPopulation statistics ePublished: 1 December 2008 Issue Published: 1 March 1967 PDF downloadLoading ...