Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan
2004; Wiley; Volume: 56; Issue: 5 Linguagem: Inglês
10.1002/ana.20290
ISSN1531-8249
AutoresKazuhiro Ishii, Akira Tamaoka, Fujio Otsuka, Nobuaki Iwasaki, Kenji Shin, Akira Matsui, Ginji Endo, Yoshito Kumagai, Tetsuro Ishii, Shin’ichi Shoji, Tsuyoshi Ogata, Mutsuo ISHIZAKI, Mikio Doi, Nobuhiro Shimojo,
Tópico(s)Methemoglobinemia and Tumor Lysis Syndrome
ResumoAbstract We noted a new clinical syndrome with prominent cerebellar symptoms in apartment building residents in Kamisu, Japan. The well that provided drinking water contained diphenylarsinic acid, a degradation product of diphenylcyanoarsine or diphenylchloroarsine, which were developed for use as chemical weapons, inducing severe vomiting and sneezing. Characteristics of diphenylarsinic acid poisoning include brainstem–cerebellar and cerebral symptoms. Mental retardation associated with brain atrophy in magnetic resonance images was evident in some infants. We must be vigilant to prevent or minimize the effects of further diphenylarsinic acid poisoning in Japan or elsewhere. Ann Neurol 2004;56:741–745
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