Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Brain development in male rats subjected to early weaning and treated with diet containing flour or flaxseed oil after 21 days until 60 days

2015; Cambridge University Press; Volume: 6; Issue: 4 Linguagem: Inglês

10.1017/s2040174415001087

2040-1752

Carolina Ribeiro Pessanha, Bianca Ferolla da Camara Boueri, Luanna Rodrigues da Costa, Maitê Rocha Ferreira, Henrique Saldanha Melo, Maíra Duque Coutinho de Abreu, Letícia Rozeno Pessôa, P. C. Alves da Silva, Aline D’Ávila Pereira, Danielle Cavalcante Ribeiro, J. Azevedo de Meneses, Carlos Alberto Soares da Costa, Gilson Teles Boaventura,

Fatty Acid Research and Health

The precocious interruption of lactation is a prime factor for developmental plasticity. Here we analyzed whether flour or flaxseed oil treatment contributes to body and brain mass in male rats subjected to early weaning. Pups were weaned for separation from their mother at 14 (early weaning, EW) and 21 days (control, C). At 21 days, some of the pups were evaluated (C21 v. EW21). After 21 days, control pups (C60) were fed a control diet. EW pups were divided into those fed a control diet (EWC60), those given flaxseed flour (EWFF60), and those given flaxseed oil (EWFO60) until 60 days. EW21 showed lower body and absolute brain mass and higher relative brain mass. At 60 days, EWC60 and EWFO60 had lower body mass. With regard to relative brain mass, EWC60 was heavier; EWFO60 had lower values compared with EWC60 and higher values compared with C60 and EWFF60. These results indicated that flaxseed flour, in comparison with flaxseed oil, contributes to brain development after EW.