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The Complete Nucleotide Sequence of Coxsackievirus A21

1989; Microbiology Society; Volume: 70; Issue: 11 Linguagem: Inglês

10.1099/0022-1317-70-11-2943

1465-2099

Pamela Hughes, C. North, Philip D. Minor, Glyn Stanway,

Respiratory viral infections research

Summary We have determined the complete nucleotide sequence of coxsackievirus A21(CAV-21), the first member of this enterovirus subgroup to be analysed in molecular detail. The sequence, which is 7401 nucleotides long, encodes an open reading frame of 2206 codons, preceded by a 5′ non-coding region of 711 nucleotides and followed by a 3′ non-coding region of 72 nucleotides plus a poly(A) tract. The most striking feature is the remarkable homology to the poliovirus (> 90% at the amino acid level) in the 3′ part of the genome. The rest of the genome is much less homologous, suggesting that CAV-21 is a recombinant virus. Rhinovirus-like characteristics, including the length of the 5′ non-coding region and a slight --U/--A imbalance in codon usage, may be related to the fact that CAV-21, like rhinoviruses, infects the upper respiratory tract. However, the sequence sheds little light on the molecular basis of the shared receptor specificity.