Portal de Periódicos da CAPES

XBP1: the last two decades

2009; BMJ; Volume: 69; Issue: Suppl 1 Linguagem: Inglês

10.1136/ard.2009.119388

1468-2060

Laurie H. Glimcher,

T-cell and B-cell Immunology

The transcription factor X box-binding protein 1 (XBP1) was isolated two decades ago in a search for regulators of major histocompatibility complex (MHC) class II gene expression. Many years of research finally revealed a protein with many functions, none of them related to the MHC. This paper provided an overview of what this multifunctional transcription factor actually does.