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Highly Efficient Chemoenzymatic Synthesis of Naturally Occurring and Non‐Natural α‐2,6‐Linked Sialosides: A P. damsela α‐2,6‐Sialyltransferase with Extremely Flexible Donor–Substrate Specificity

2006; Wiley; Volume: 45; Issue: 24 Linguagem: Inglês

10.1002/anie.200600572

1521-3773

Hai Yu, Shengshu Huang, Harshal A. Chokhawala, Mingchi Sun, Haojie Zheng, Xi Chen,

Enzyme Production and Characterization

Angewandte Chemie International EditionVolume 45, Issue 24 p. 3938-3944 Communication Highly Efficient Chemoenzymatic Synthesis of Naturally Occurring and Non-Natural α-2,6-Linked Sialosides: A P. damsela α-2,6-Sialyltransferase with Extremely Flexible Donor–Substrate Specificity† Hai Yu Dr., Hai Yu Dr. Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA, Fax: (+1) 530-752-8995Search for more papers by this authorShengshu Huang, Shengshu Huang Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA, Fax: (+1) 530-752-8995Search for more papers by this authorHarshal Chokhawala, Harshal Chokhawala Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA, Fax: (+1) 530-752-8995Search for more papers by this authorMingchi Sun, Mingchi Sun Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA, Fax: (+1) 530-752-8995Search for more papers by this authorHaojie Zheng, Haojie Zheng Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA, Fax: (+1) 530-752-8995Search for more papers by this authorXi Chen Prof. Dr., Xi Chen Prof. Dr. [email protected] Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA, Fax: (+1) 530-752-8995Search for more papers by this author Hai Yu Dr., Hai Yu Dr. Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA, Fax: (+1) 530-752-8995Search for more papers by this authorShengshu Huang, Shengshu Huang Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA, Fax: (+1) 530-752-8995Search for more papers by this authorHarshal Chokhawala, Harshal Chokhawala Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA, Fax: (+1) 530-752-8995Search for more papers by this authorMingchi Sun, Mingchi Sun Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA, Fax: (+1) 530-752-8995Search for more papers by this authorHaojie Zheng, Haojie Zheng Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA, Fax: (+1) 530-752-8995Search for more papers by this authorXi Chen Prof. Dr., Xi Chen Prof. Dr. [email protected] Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA, Fax: (+1) 530-752-8995Search for more papers by this author First published: 01 June 2006 https://doi.org/10.1002/anie.200600572Citations: 202 † The authors thank Prof. Ajit Varki for providing plasmids containing the P. damsela α-2,6-sialyltransferase gene in a TOPO vector. This work was supported by Mizutani Foundation for Glycoscience and NIH R01M076360. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Just relax: A one-pot, three-enzyme chemoenzymatic synthetic approach is highly efficient for obtaining complex sialosides that contain diverse naturally occurring sialic acid modifications. α-2,6-Linked sialosides containing twelve naturally occurring sialic acid forms and seven non-natural sialic acid forms have been obtained. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600572_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume45, Issue24June 12, 2006Pages 3938-3944 RelatedInformation