Produção Nacional
Revisado por pares
Physical, Chemical, and Immunohistochemical Investigation of the Damage to Salivary Glands in a Model of Intoxication with Aluminium Citrate
2014; Multidisciplinary Digital Publishing Institute; Volume: 11; Issue: 12 Linguagem: Inglês
10.3390/ijerph111212429
ISSN1661-7827
AutoresNatacha Malu Miranda da Costa, Russell Santiago Correa, Ismael Júnior, Adilson Figueiredo, Kelly Vilhena, Paulo Mecenas, Francisco Bruno Teixeira, Nayana Ferreira, João B. Pereira, Kelly das Graças Fernandes Dantas, Marcia Silva, Ademir Ferreira da Silva-Júnior, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro, Rafael Rodrigues Lima,
Tópico(s)Heavy Metal Exposure and Toxicity
ResumoAluminum absorption leads to deposits in several tissues. In this study, we have investigated, to our knowledge for the first time, aluminum deposition in the salivary glands in addition to the resultant cellular changes in the parotid and submandibular salivary glands in a model of chronic intoxication with aluminum citrate in rats. Aluminum deposits were observed in the parotid and submandibular glands. Immunohistochemical evaluation of cytokeratin-18 revealed a decreased expression in the parotid gland with no changes in the submandibular gland. A decreased expression of α-smooth muscle actin was observed in the myoepithelial cells of both glands. The expression of metallothionein I and II (MT-I/II), a group of metal-binding proteins, which are useful indicators for detecting physiological responses to metal exposure, was higher in both glands. In conclusion, we have shown that at a certain time and quantity of dosage, aluminum citrate promotes aluminum deposition in the parotid and submandibular glands, leads to an increased expression of MT-I/II in both the glands, damages the cytoskeleton of the myoepithelial cells in both glands, and damages the cytoskeleton of the acinar/ductal cells of the parotid glands, with the submandibular glands showing resistance to the toxicity of the latter.
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