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BIBTEX RIS

Matrix metalloproteinase‐7 and matrix metalloproteinase‐25 in oral tongue squamous cell carcinoma

2013; Wiley; Volume: 36; Issue: 12 Linguagem: Inglês

10.1002/hed.23539

1097-0347

Laura K. Mäkinen, Valtteri Häyry, Jaana Hagström, Timo Sorsa, Fabrício Passador‐Santos, Harri Keski–Säntti, Jari Haukka, Antti Mäkitie, Caj Haglund, Timo Atula,

Cell Adhesion Molecules Research

Predicting the clinical course of early-stage oral tongue squamous cell carcinoma (SCC) is challenging. As matrix metalloproteinases (MMPs) are enzymes associated with invasion, metastasis, and poor survival in many cancers, we examined MMP-7 and MMP-25 in oral tongue SCC.We used tissue microarray (TMA) technique and immunohistochemistry to study the expression of MMP-7 and MMP-25 in 73 patients with stage I to II oral tongue SCC and compared their immunoexpressions with clinical data.Immunohistochemistry revealed MMP-7 and MMP-25 expression in 90% (n = 63 of 70) and 90% (n = 64 of 71) of the tumors, respectively. MMP-7 protein expression was associated with presence of occult cervical metastases (odds ratio [OR], 3.67; p = .013), increased invasion depth (OR, 4.60; p = .005), and higher tumor grade (OR, 3.30; p = .007). MMP-7 expression was predictive for poor outcome (p = .021). Immunostaining of MMP-25 did not correlate with any clinical parameters.We conclude that MMP-7, but not MMP-25, expression may have prognostic significance in early-stage oral tongue SCC.