Radiochemical separation of no-carrier-added radioniobium from zirconiu targets for application of 90 Nb-labelled compounds
2002; R. Oldenbourg Verlag; Volume: 90; Issue: 7 Linguagem: Inglês
10.1524/ract.2002.90.7_2002.411
ISSN2193-3405
AutoresS. Busse, Jörg Brockmann, Frank Rösch,
Tópico(s)Chemical Synthesis and Characterization
ResumoSummary The radioisotope 90 Nb is a positron emitter with a relatively high positron branching of 51% and a rather low β + -energy of E mean = 662 keV E max = 1.5 MeV) with potential for application in positron emission tomography (PET). Its half-life of 14.6 h makes it especially promising for the quantitative investigation of biological processes with slow distribution kinetics. An advantageous production route of 90 Nb is the nat Zr( p , n ) 90 Nb process. To separate nca (no-carrier-added) radioniobium from macroscopic amounts of irradiated zirconium targets, an effective two step separation procedure was developed. A liquid-liquid extraction using N-benzoyl-N-phenylhydroxylamine (BPHA) in CHCl 3 was applied first to separate the bulk of the zirconium matrix with a Zr separation coefficient of about 10 4 , followed by anion-exchange chromatography for high grade purification of nca radioniobium. A sufficiently high decontamination factor of > 2 × 10 7 and an overall radiochemical yield of nca 90 Nb of about 70% was achieved within about 3 hours.
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