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Haemoperfusion in Amanita phalloides Poisoning

1995; Oxford University Press; Volume: 41; Issue: 6 Linguagem: Inglês

10.1093/tropej/41.6.371

1465-3664

Dolly Yafet AJİ, Salim Çalışkan, Ahmet Nayır, Afife Mat, Büşra Can, Zeynel YAŞAR, Hülya Özşahin, Fügen Çokuğraş, Lale Sever,

Phytochemistry and Bioactivity Studies

Amanita phalloides is responsible for about 90 per cent of all fatal cases of mushroom intoxication. The amatoxins, the main toxic component of these fungi, are responsible for gastro-intestinal symptoms, as well as hepatic and renal failure. Three brothers with Amanita phalloides poisoning were admitted with gastro-intestinal symptoms beginning 12 h after ingestion. Jaundice, hepatomegaly and neurological symptoms were not present, but the liver enzymes were moderately increased. Alfa-amanitin was detected in sera of all patients. All patients underwent charcoal bemoperfusion and two of them had additional haemodialysis along with conservative therapy. Liver enzymes that showed marked increase on the second day of therapy decreased to normal levels on the 28th day. All of our patients survived. The life saving role of early haemoperfusion in Amanita phalloides poisoning is emphasized.