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Urinary excretion of pseudouridine in patients with hepatocellular carcinoma

1986; Wiley; Volume: 57; Issue: 8 Linguagem: Inglês

10.1002/1097-0142(19860415)57

1097-0142

Shinsuke Tamura, Yoshiki Amuro, Takashi Nakano, Junji Fujii, Yuji Moriwaki, Tetsuya Yamamoto, Toshikazu Hada, Kazuya Higashino,

Cancer Diagnosis and Treatment

CancerVolume 57, Issue 8 p. 1571-1575 ArticleFree Access Urinary excretion of pseudouridine in patients with hepatocellular carcinoma Shinsuke Tamura MD, Corresponding Author Shinsuke Tamura MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanThird Department of Internal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663, Japan===Search for more papers by this authorYoshiki Amuro MD, Yoshiki Amuro MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this authorTakashi Nakano MD, Takashi Nakano MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this authorJunji Fujii MD, Junji Fujii MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this authorYuji Moriwaki MD, Yuji Moriwaki MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this authorTetsuya Yamamoto MD, Tetsuya Yamamoto MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this authorToshikazu Hada MD, Toshikazu Hada MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this authorKazuya Higashino MD, Kazuya Higashino MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this author Shinsuke Tamura MD, Corresponding Author Shinsuke Tamura MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanThird Department of Internal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663, Japan===Search for more papers by this authorYoshiki Amuro MD, Yoshiki Amuro MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this authorTakashi Nakano MD, Takashi Nakano MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this authorJunji Fujii MD, Junji Fujii MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this authorYuji Moriwaki MD, Yuji Moriwaki MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this authorTetsuya Yamamoto MD, Tetsuya Yamamoto MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this authorToshikazu Hada MD, Toshikazu Hada MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this authorKazuya Higashino MD, Kazuya Higashino MD Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanSearch for more papers by this author First published: 15 April 1986 https://doi.org/10.1002/1097-0142(19860415)57:8 3.0.CO;2-RCitations: 32AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract The urinary concentration of pseudouridine, primarily a degradation product of transfer ribonucleic acid, was determined by high-performance liquid chromatography in 23 patients with primary hepatocellular carcinoma, 13 patients with liver cirrhosis, and 24 healthy controls. The urinary concentration of pseudouridine in the patients with hepatocellular carcinoma was significantly higher than that in the patients with liver cirrhosis or the healthy controls. Sixteen (70%) of the 23 patients with hepatocellular carcinoma had urinary pseudouridine levels higher than the mean value for the healthy controls plus 2 standard deviations. Nine of the 13 patients (69%) who had a serum alpha-fetoprotein level below 400 ng/ml, had elevated urinary pseudouridine levels. 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Citing Literature Volume57, Issue815 April 1986Pages 1571-1575 ReferencesRelatedInformation