Produção Nacional
Revisado por pares
Coronary calcification score is higher in type 2 diabetic patients with cardiovascular autonomic neuropathy
2007; Medical Association of São Paulo; Volume: 125; Issue: 2 Linguagem: Inglês
10.1590/s1516-31802007000200013
ISSN1806-9460
AutoresLuiz Clemente Rolim, Paulo Henrique Rezende, Joäo Roberto de Sá, Fábio Nasri, Romeu Meneghello, Antônio Roberto Chacra, Sérgio Atala Dib,
Tópico(s)Cardiac electrophysiology and arrhythmias
ResumoHowever, the pathophysiology of this association is still under discussion. Silent myocardial ischemia is common in diabetics with CAN. Both parasympathetic and sympathetic pathways may be involved. 3 There are data suggesting that the extent of coronary calcifi cation and the development of ischemic heart disease seem to be closely related to diabetic complications. 4 The present study was aimed at investigating the degree of coronary artery calcifi cation in type 2 diabetes mellitus individuals (T2DMs) with CAN (WCAN; n = 9) and without CAN (WOCAN; n = 9). A pilot study was conducted on 18 T2DMs, using the following inclusion criteria: diabetes diagnosed more than 10 years earlier (TDDM), normal resting electrocardiogram, non-smoking and being asymptomatic for coronary artery disease. The exclusion criteria were drug use for hyperlipidemia, glomerular fi ltration rate lower than 50 ml/min, congestive heart failure and history of stroke. Informed written consent was obtained from all patients and the Ethics Board of Universidade Federal de Sao Paulo had previously approved the protocol. Fasting serum C-peptide (normal value): 0.36-3.4 ng/ml), HbA1c (A1c Hemoglobin; normal value: 3.4-6.8%), lipids and urinary albumin/creatinine ratio were measured by standard laboratory tests. Arterial hypertension and electrocardiogram (EKG) (Marquette MAC500) were also evaluated. Electron beam computed tomography imaging was performed using an ultrafast scanner (C-150 Imatron) and the coronary calcium score (CaS) was calculated using Agatston’s method. 5 The CAN diagnosis was based on two or more abnormal cardiovascular autonomic tests on two different occasions. These tests were, fi rstly, the heart rate variability (HRV) at six deep breaths per minute (mean); secondly the 30:15 ratio appraised for the relationship between the longest RR interval of EKG around the thirtieth beat and the shortest interval around the fi fteenth beat after the patient was standing; and fi nally, the orthostatic hypotension that was present when systolic blood pressure decreased by at least 20 mmHg in the third minute of standing. The differences between WCAN and WOCAN were analyzed using the Mann-Whitney or Student t test. The signifi cance level chosen was 0.05 for all statistical tests. The two groups did not differ in relation to: sex (males: 44.4% versus 55.5%), age (54.7 ± 5.5 versus 59.2 ± 3.9 years), TDDM (14.4 ± 4.0 versus 13.7 ± 2.9 years), body mass index (28.2 ± 2.9 versus 27.6 ± 4.0 kg/m 2
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