Renal transplantation in baboons under FK 506
1990; Elsevier BV; Volume: 22; Issue: 1 Linguagem: Inglês
ISSN
1873-2623
AutoresOscar Imventarza, S Todo, G Eiras, Yutaka Ueda, Hiroshi Furukawa, Wu Ym, Yihong Zhu, A. Oks, Jake Demetris, Starzl Te,
Tópico(s)Neuroinflammation and Neurodegeneration Mechanisms
ResumoFK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native nephrectomy. Untreated baboons died after 9.2 ± 4.0 SD days. When FK 506 was given orally for 90 days, survival with the optimum dose was 74.6 ± 28.9 days; this allowed maximum credit for each individual animal of 90 days. A 3-day course of intramuscular FK 506 started on postoperative day 4 allowed 1- to 2-month survival. Delayed rejection in these baboons as well as in those treated daily for 90 days with FK could sometimes be reversed temporarily with a second 3-day course. The doses required for a good therapeutic effect were 10 times greater in baboons than in dogs, a finding that may reflect a species difference of lymphocyte sensitivity to this drug. FK appeared to be relatively nontoxic in subhuman primates, and it remains a promising drug for clinical trial. © 1989.
Referência(s)