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Clinical manifestations of mannan-binding lectin deficiency

2005; Elsevier BV; Volume: 43; Issue: 1-2 Linguagem: Inglês

10.1016/j.molimm.2005.06.018

1872-9142

Steffen Thiel, Pernille Frederiksen, Jens C. Jensenius,

Blood groups and transfusion

Mannan-binding lectin (MBL) is a plasma protein of the innate immune system with the ability to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More than 10% of the general population may, depending on definition, be classified as MBL deficient, underlining the redundancy of the immune system. Ongoing research attempt to illuminate at which conditions MBL deficiency may lead to disease. With examples, this review illustrates the diversity of results obtained so far.