Molecular and physiological functions of sphingosine 1-phosphate transporters
2013; Elsevier BV; Volume: 1841; Issue: 5 Linguagem: Inglês
10.1016/j.bbalip.2013.07.012
ISSN1879-2618
AutoresTsuyoshi Nishi, Naoki Kobayashi, Yu Hisano, Atsuo Kawahara, Akihito Yamaguchi,
Tópico(s)Endoplasmic Reticulum Stress and Disease
ResumoSphingosine 1-phosphate (S1P) is a lipid mediator that plays important roles in diverse cellular functions such as cell proliferation, differentiation and migration. S1P is synthesized inside the cells and subsequently released to the extracellular space, where it binds to specific receptors that are located on the plasma membranes of target cells. Accumulating recent evidence suggests that S1P transporters including SPNS2 mediate S1P release from the cells and are involved in the physiological functions of S1P. In this review, we discuss recent advances in our understanding of the mechanism and physiological functions of S1P transporters. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology.
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