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Increased specificity of antibody detection in surgical patients with invasive candidiasis with cytoplasmic antigens depleted of mannan residues

1993; American Society for Microbiology; Volume: 31; Issue: 4 Linguagem: Inglês

10.1128/jcm.31.4.994-997.1993

1098-660X

A J van Deventer, Hans van Vliet, Linda Voogd, W.C.J. Hop, Wil H. F. Goessens,

Microfluidic and Bio-sensing Technologies

In this study, it was shown that the diagnostic accuracy of antibody detection by a counterimmunoelectrophoresis technique could be improved by using cytoplasmic antigens depleted of mannan residues. The specificity of the counterimmunoelectrophoresis increased from 28.6 to 78.6% when cytoplasmic antigens depleted of mannan were used, while the sensitivity slightly decreased from 80 to 70%.