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BIBTEX RIS

Effect of grepafloxacin on cytokine production in vitro

2000; Oxford University Press; Volume: 46; Issue: 1 Linguagem: Inglês

10.1093/jac/46.1.91

ISSN

1460-2091

Autores

Yukihisa Ono,

Tópico(s)

Immune Response and Inflammation

Resumo

The effect of a new quinolone antibacterial agent, grepafloxacin, on the production of cytokines was investigated using lipopolysaccharide-stimulated human peripheral blood cells. Grepafloxacin 1-30 mg/L inhibited the production of interleukin 1alpha (IL-1alpha) and IL-1beta, and the expression of IL-1alpha, IL-1beta, tumour necrosis factor alpha (TNFalpha), IL-6 and IL-8 mRNA. These results suggest that the inhibitory effect of grepafloxacin is exerted, in part, at the gene transcription level.

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