Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents
2010; Elsevier BV; Volume: 46; Issue: 2 Linguagem: Inglês
10.1016/j.ejmech.2010.12.004
ISSN1768-3254
AutoresÄhmed Kamal, E. Vijaya Bharathi, Jhansi Reddy, M. Janaki Ramaiah, D. Dastagiri, M. Kashi Reddy, Viswanath Arutla, Lakshminarayan Reddy Teegala, Thokhir Basha Shaik, S. N. C. V. L. Pushpavalli, Manika Pal Bhadra,
Tópico(s)Synthesis and Characterization of Heterocyclic Compounds
ResumoA series of new 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydro quinazolinone hybrids with different linker architectures have been designed and synthesized. These compounds have been evaluated for their anticancer activity. One of the compounds 4c amongst this series has shown promising anticancer activity. Further some detailed biological assays relating to the cell cycle aspects and tubulin depolymerization activity have been examined with a view to understand the mechanism of action of this conjugate.
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