Portal de Periódicos da CAPES

More efficient redox biocatalysis by utilising 1,4-butanediol as a ‘smart cosubstrate’

2012; Royal Society of Chemistry; Volume: 15; Issue: 2 Linguagem: Inglês

10.1039/c2gc36797a

1463-9270

Selin Kara, Dominik Spickermann, Joerg H. Schrittwieser, Christian Leggewie, Willem J. H. van Berkel, Isabel W. C. E. Arends, Frank Hollmann,

Carbon dioxide utilization in catalysis

1,4-Butanediol is shown to be an efficient cosubstrate to promote NAD(P)H-dependent redox biocatalysis. The thermodynamically and kinetically inert lactone coproduct makes the regeneration reaction irreversible. Thereby not only the molar surplus of cosubstrate is dramatically reduced but also faster reaction rates are obtained.