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Inhibitory effects of L-glutamine on the aspirin-induced gastric lesions in the rat

1974; Oxford University Press; Volume: 26; Issue: 8 Linguagem: Inglês

10.1111/j.2042-7158.1974.tb10672.x

2042-7158

Shigeo Okabe, Koji Takeuchi, Keita Nakamura, Keijiro Takagi,

Gastroesophageal reflux and treatments

Abstract The effects of an amino acid, L-glutamine, on aspirin-induced gastric lesions and gastric secretion were studied in either intact or pylorus-ligated rats. L-Glutamine had a pronounced inhibitory effect on gastric lesions induced by aspirin administered by oral, intraperitoneal, or intraduodenal routes to intact or pylorus-ligated rats. By the oral route the inhibition was dose-related. However, L-glutamine given either intraduodenally or intraperitoneally did not show any appreciable effects on gastric lesions induced by orally administered aspirin in pylorus-ligated rats. One mechanism of L-glutamine protection was inhibition of a back diffusion of gastric acid caused by aspirin and this was demonstrated in pylorus-ligated rats. The reduction in H+ and increase in Na+ concentrations in the lumen caused by aspirin was returned to normal by increasing doses of L-glutamine. In addition, L-glutamine was considered to inhibit the back diffusion of acid caused by pylorus ligation per se, because the amino-acid produced an increment of H+ and reduction of Na+ and K+ in comparison with the control group. The role of pepsin on L-glutamine protection was negligible.