Coexistence of EGFR mutation and ALK translocation in NSCLC: Literature review and case report of response to gefitinib
2013; Elsevier BV; Volume: 81; Issue: 2 Linguagem: Inglês
10.1016/j.lungcan.2013.04.009
ISSN1872-8332
AutoresCarlotta Santelmo, Alessandra Ravaioli, Eleonora Barzotti, Maximilian Papi, B. Poggi, Francesco Maria Drudi, M Mangianti, Marta Salvi, Lucio Crinó,
Tópico(s)Pancreatic and Hepatic Oncology Research
ResumoThe coexistence of EGFR and ALK-EML4 gene mutations represents a rare event (about 1%) in patients with non small cell lung cancer (NSCLC) and the few cases described in the literature have all been treated by different methods. We present the case of a 52-year-old woman with adenocarcinoma of the lung whose tumor had this double genetic aberration. The patient was immediately treated with gefitinib because the tumor was judged inoperable, but after two months she obtained an important clinical remission and was submitted to radical surgery. She is currently undergoing adjuvant treatment with gefitinib. A review of the literature on this double genetic aberration highlighted that further research is needed to define the best therapeutic approach.
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