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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Characterization of the Influence of some Cyclodextrins on the Stratum Corneum from the Hairless Mouse

1997; Oxford University Press; Volume: 49; Issue: 4 Linguagem: Inglês

10.1111/j.2042-7158.1997.tb06813.x

ISSN

2042-7158

Autores

Maria Vitória Lopes Badra Bentley, Renata Fonseca Vianna Lopez, Susan Wilson, J H Collett,

Tópico(s)

Bee Products Chemical Analysis

Resumo

Differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy and transmission electron microscopy (TEM) have been used to determine the influence of beta-cyclodextrin (beta-CyD), hydroxypropyl-beta-CyD (HP-beta-CyD) and gamma-CyD on the structural properties of the stratum corneum from the hairless mouse. Some modest changes in the stratum corneum lipid transition temperature were induced by HP-beta-CyD and blue shifts were observed in the FTIR spectra of the C-H asymmetric and symmetric stretching of the lipids from the stratum corneum. Results from TEM studies indicated that HP-beta-CyD caused removal and possible disorganization of the lipid matrix that envelopes the corneocytes of the stratum corneum, whereas no effect was seen after treatment of the samples with beta-CyD and gamma-CyD. These results suggest that HP-beta-CyD can increase the permeability of the stratum corneum possibly as a result of extraction of lipids, and might thus enhance drug permeation through the skin.

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