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Arkadia enhances BMP signalling through ubiquitylation and degradation of Smad6

2015; Oxford University Press; Volume: 158; Issue: 1 Linguagem: Inglês

10.1093/jb/mvv024

1756-2651

Yoshiharu Tsubakihara, Atsuhiko Hikita, Shin Yamamoto, Satoshi Matsushita, Natsuki Matsushita, Yusuke Oshima, Keiji Miyazawa, Takuya Imamura,

Developmental Biology and Gene Regulation

Journal Article Arkadia enhances BMP signalling through ubiquitylation and degradation of Smad6 Get access Yutaro Tsubakihara, Yutaro Tsubakihara 1 Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime; 2 Division of Bio-imaging, Proteo-Science Center, Ehime University, Shitsukawa, Toon, Ehime; 3 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo; 4 Department of Gastroenterology and Metabiology, Ehime University, Shitsukawa, Toon, Ehime; 5 Translational Research Center, Ehime University Hospital, Shitsukawa, Toon, Ehime; and 6 Department of Biochemistry, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Atsuhiko Hikita, Atsuhiko Hikita 1 Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime; 2 Division of Bio-imaging, Proteo-Science Center, Ehime University, Shitsukawa, Toon, Ehime; 3 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo; 4 Department of Gastroenterology and Metabiology, Ehime University, Shitsukawa, Toon, Ehime; 5 Translational Research Center, Ehime University Hospital, Shitsukawa, Toon, Ehime; and 6 Department of Biochemistry, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Shin Yamamoto, Shin Yamamoto 1 Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime; 2 Division of Bio-imaging, Proteo-Science Center, Ehime University, Shitsukawa, Toon, Ehime; 3 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo; 4 Department of Gastroenterology and Metabiology, Ehime University, Shitsukawa, Toon, Ehime; 5 Translational Research Center, Ehime University Hospital, Shitsukawa, Toon, Ehime; and 6 Department of Biochemistry, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Sachi Matsushita, Sachi Matsushita 1 Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime; 2 Division of Bio-imaging, Proteo-Science Center, Ehime University, Shitsukawa, Toon, Ehime; 3 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo; 4 Department of Gastroenterology and Metabiology, Ehime University, Shitsukawa, Toon, Ehime; 5 Translational Research Center, Ehime University Hospital, Shitsukawa, Toon, Ehime; and 6 Department of Biochemistry, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Natsuki Matsushita, Natsuki Matsushita 1 Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime; 2 Division of Bio-imaging, Proteo-Science Center, Ehime University, Shitsukawa, Toon, Ehime; 3 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo; 4 Department of Gastroenterology and Metabiology, Ehime University, Shitsukawa, Toon, Ehime; 5 Translational Research Center, Ehime University Hospital, Shitsukawa, Toon, Ehime; and 6 Department of Biochemistry, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yusuke Oshima, Yusuke Oshima 1 Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime; 2 Division of Bio-imaging, Proteo-Science Center, Ehime University, Shitsukawa, Toon, Ehime; 3 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo; 4 Department of Gastroenterology and Metabiology, Ehime University, Shitsukawa, Toon, Ehime; 5 Translational Research Center, Ehime University Hospital, Shitsukawa, Toon, Ehime; and 6 Department of Biochemistry, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Keiji Miyazawa, Keiji Miyazawa 1 Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime; 2 Division of Bio-imaging, Proteo-Science Center, Ehime University, Shitsukawa, Toon, Ehime; 3 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo; 4 Department of Gastroenterology and Metabiology, Ehime University, Shitsukawa, Toon, Ehime; 5 Translational Research Center, Ehime University Hospital, Shitsukawa, Toon, Ehime; and 6 Department of Biochemistry, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Takeshi Imamura Takeshi Imamura * 1 Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime; 2 Division of Bio-imaging, Proteo-Science Center, Ehime University, Shitsukawa, Toon, Ehime; 3 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo; 4 Department of Gastroenterology and Metabiology, Ehime University, Shitsukawa, Toon, Ehime; 5 Translational Research Center, Ehime University Hospital, Shitsukawa, Toon, Ehime; and 6 Department of Biochemistry, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan *Takeshi Imamura, Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan. Tel: +81-89-960-5044 , Fax: +81-89-960-5052 , email: timamura-ind@umin.ac.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 158, Issue 1, July 2015, Pages 61–71, https://doi.org/10.1093/jb/mvv024 Published: 11 March 2015 Article history Received: 05 November 2014 Accepted: 17 January 2015 Published: 11 March 2015