A facile one-pot synthesis of β-keto sulfones from ketones under solvent-free conditions
2006; Elsevier BV; Volume: 47; Issue: 25 Linguagem: Inglês
10.1016/j.tetlet.2006.04.076
ISSN1873-3581
AutoresDalip Kumar, Swapna Sundaree, V. S. Rao, Rajender S. Varma,
Tópico(s)Organic and Inorganic Chemical Reactions
ResumoAn easy solvent-free method is described for the conversion of ketones into β-keto sulfones in high yields that involves the in situ generation of α-tosyloxyketones, followed by nucleophilic substitution with sodium arene sulfinate in the presence of tetra-butylammonium bromide at room temperature. The salient features of this one-pot protocol are short reaction times, cleaner reaction profiles, and simple work-up that precludes the use of toxic solvents.
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