Portal de Periódicos da CAPES

Clinical mini-review: systemic lupus erythematosus and the eye

2004; Taylor & Francis; Volume: 12; Issue: 2 Linguagem: Inglês

10.1080/09273940490895308

1744-5078

Russell W. Read,

Immunotherapy and Immune Responses

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease, the exact etiology of which is unknown. It is characterized by the production of pathological autoantibodies which adhere to cellular surfaces or form immune complexes which deposit in tissue, leading to end-organ damage via inflammatory mechanisms including complement activation. SLE may manifest itself in any organ system. In the eye, keratoconjunctivitis sicca is the most common finding. Other ophthalmic sites of involvement include the cornea, conjunctiva, episclera, sclera, uveal tract, retina, vasculature, optic nerve, and orbit. Therapy varies based on the disease manifestation and severity.