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Sesquiterpene Farnesol Contributes to Increased Susceptibility to β-Lactams in Strains of Burkholderia pseudomallei

2012; American Society for Microbiology; Volume: 56; Issue: 4 Linguagem: Inglês

10.1128/aac.05885-11

ISSN

1098-6596

Autores

Raimunda Sâmia Nogueira Brilhante, Luiz Alberto Soares Valente, Marcos Fábio Gadelha Rocha, Tereza J. P. G. Bandeira, Rossana de Aguiar Cordeiro, Rita Amanda Chaves de Lima, João Jaime Giffoni Leite, Joyce Fonteles Ribeiro, Jorge Fernando Pereira, Débora de Souza Collares Maia Castelo‐Branco, A. J. Monteiro, José Júlio Costa Sidrim,

Tópico(s)

Burkholderia infections and melioidosis

Resumo

This study aimed to evaluate the in vitro combination of farnesol and β-lactams against Burkholderia pseudomallei. A total of 12 β-lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 μM. The combination of this compound with β-lactams resulted in statistically significant β-lactam MIC reduction (P ≤ 0.05). This study provides new perspectives for the use of farnesol combined with β-lactam antibiotics against strains of B. pseudomallei.

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