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Refined algorithm and computer program for calculating all non–negative fluxes admissible in steady states of biochemical reaction systems with or without some flux rates fixed

1993; Oxford University Press; Volume: 9; Issue: 1 Linguagem: Inglês

10.1093/bioinformatics/9.1.79

1367-4811

R. Schuster, Stefan Schuster,

Microbial Metabolic Engineering and Bioproduction

A refined algorithm together with a computer procedure for determining the complete set of non–negative, steady–state fluxes in biochemical reaction systems of any complexily, with or without some flux rates fixed, is given. It is shown that this set is a convex polyhedron, which may or may not be bounded. The algorithm is illustrated by several examples; one of them concerns intermediary metabolism. A computer cade in standard C is presented.