Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety
2000; Elsevier BV; Volume: 10; Issue: 2 Linguagem: Inglês
10.1016/s0960-894x(99)00646-0
ISSN1464-3405
AutoresYong Koo Kang, Kye Jung Shin, Kyung Ho Yoo, Kyung Jae Seo, Chang Yong Hong, Chang‐Seok Lee, Seung‐Yong Park, Dong Jin Kim, Sang Woo Park,
Tópico(s)Cancer therapeutics and mechanisms
ResumoThe synthesis and biological activity of a series of new 1beta-methylcarbapenems 1a-g containing 5'-isoxazolopyrrolidin-3'-ylthio derivatives as C-2 side chain are described. Most compounds exhibited potent and well-balanced antibacterial activity as well as high stability to DHP-I comparable to that of meropenem. 1e and 1c showed the best combination of antibacterial activity and stability to DHP-I, respectively.
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