Portal de Periódicos da CAPES

Human Mismatch Repair Genes and Their Association with Hereditary Non-Polyposis Colon Cancer

1994; Cold Spring Harbor Laboratory Press; Volume: 59; Linguagem: Inglês

10.1101/sqb.1994.059.01.037

1943-4456

Richard D. Kolodner, N. R. Hall, J. Russell Lipford, Michael Kane, Milind Rao, P. J. Morrison, Lorinette S. Wirth, P J Finan, John Burn, P D Chapman, Christine Earabino, Elizabeth Merchant, D. Timothy Bishop, JudyE. Garber, Christian Bronner, Sean M. Baker, Gwynedd Warren, Lacy Smith, Annika Lindblom, Pia Tannergård, Roni J. Bollag, Aruna Godwin, D.C. Ward, Magnus Nordenskjöld, R. Michael Liskay, N G Copeland, N A Jenkins, Mary Kay Lescoe, Amy Ewel, S. Lee, J. P. CROZER GRIFFITH, Richard Fishel,

RNA and protein synthesis mechanisms

Hereditary non-polyposis colon cancer (HNPCC) may affect up to 1 in 200 people in industrialized nations (Bishop and Thomas 1990; Lynch et al. 1991, 1993; Peltomaki et al. 1993b). Four genes have been identified in which inherited mutations appear to cause HNPCC. hMSH2 on chromosome 2p21–22 appears to account for up to 60% of HNPCC (Fishel et al. 1993; Leach et al. 1993; Sandkuijl and Bishop 1993; Nystrom-Lahti et al. 1994), hMLH1 on chromosome 3p21 appears to account for up to 30% of HNPCC (Bronner et al. 1994; Nystrom-Lahti et al. 1994; Papadopoulos et al. 1994), and hPMS1 on chromosome 2q31–33 and hPMS2 on chromosome 7p21 may account for 5% of HNPCC (Nicolaides et al. 1994).