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Oxidative stress adaptation in aggressive prostate cancer may be counteracted by the reduction of glutathione reductase

2012; Wiley; Volume: 2; Issue: 1 Linguagem: Inglês

10.1016/j.fob.2012.05.001

2211-5463

Mariana Freitas, Inês Baldeiras, Teresa Proença, Vera Alves, Anabela Mota‐Pinto, Ana Bela Sarmento‐Ribeiro,

Inflammatory mediators and NSAID effects

PC3 shows higher ROS production but also the highest GSH levels and Gl‐Red activity, possibly contributing to oxidative stress resistance. This is also associated with higher mitochondrial membrane potential, TAS and lower lipid peroxidation. On the other hand, we identified Gl‐Red activity reduction as a new strategy in overcoming oxidative stress resistance, by inducing H 2 O 2 cytotoxicity. Therefore these results suggest Gl‐Red activity reduction as a new potential therapeutic approach, in prostate cancer.