Changes in the melanocortin receptors in the hypothalamus of a rat model of cancer cachexia
2012; Wiley; Volume: 66; Issue: 8 Linguagem: Inglês
10.1002/syn.21559
ISSN1098-2396
AutoresMasami Suzuki, Minoru Narita, Maho Ashikawa, Sadayoshi Furuta, Motohiro Matoba, Hiroki Sasaki, Kazuyoshi Yanagihara, Kiyoshi Terawaki, Tsutomu Suzuki, Yasuhito Uezono,
Tópico(s)Biochemical Analysis and Sensing Techniques
ResumoSynapseVolume 66, Issue 8 p. 747-751 Short Communication Changes in the melanocortin receptors in the hypothalamus of a rat model of cancer cachexia Masami Suzuki, Masami Suzuki Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanSearch for more papers by this authorMinoru Narita, Minoru Narita Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanSearch for more papers by this authorMaho Ashikawa, Maho Ashikawa Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanSearch for more papers by this authorSadayoshi Furuta, Sadayoshi Furuta Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanSearch for more papers by this authorMotohiro Matoba, Motohiro Matoba Division of Palliative Medicine and Psycho-Oncology Palliative Care Team, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanSearch for more papers by this authorHiroki Sasaki, Hiroki Sasaki Division of Genetics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanSearch for more papers by this authorKazuyoshi Yanagihara, Kazuyoshi Yanagihara Laboratory of Molecular Cell Biology, Department of Life Sciences, Yasuda Woman's University Faculty of Pharmacy, 13-1 Yasuhigashi 6-chome, Asaminami-ku, Hiroshima 731-0153, JapanSearch for more papers by this authorKiyoshi Terawaki, Kiyoshi Terawaki Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanSearch for more papers by this authorTsutomu Suzuki, Tsutomu Suzuki Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanSearch for more papers by this authorYasuhito Uezono, Corresponding Author Yasuhito Uezono [email protected] Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanDivision of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, JapanSearch for more papers by this author Masami Suzuki, Masami Suzuki Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanSearch for more papers by this authorMinoru Narita, Minoru Narita Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanSearch for more papers by this authorMaho Ashikawa, Maho Ashikawa Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanSearch for more papers by this authorSadayoshi Furuta, Sadayoshi Furuta Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanSearch for more papers by this authorMotohiro Matoba, Motohiro Matoba Division of Palliative Medicine and Psycho-Oncology Palliative Care Team, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanSearch for more papers by this authorHiroki Sasaki, Hiroki Sasaki Division of Genetics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanSearch for more papers by this authorKazuyoshi Yanagihara, Kazuyoshi Yanagihara Laboratory of Molecular Cell Biology, Department of Life Sciences, Yasuda Woman's University Faculty of Pharmacy, 13-1 Yasuhigashi 6-chome, Asaminami-ku, Hiroshima 731-0153, JapanSearch for more papers by this authorKiyoshi Terawaki, Kiyoshi Terawaki Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanSearch for more papers by this authorTsutomu Suzuki, Tsutomu Suzuki Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanSearch for more papers by this authorYasuhito Uezono, Corresponding Author Yasuhito Uezono [email protected] Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanDivision of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, JapanSearch for more papers by this author First published: 27 March 2012 https://doi.org/10.1002/syn.21559Citations: 8Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Acharyya S,Butchbach ME,Sahenk Z,Wang H,Saji M,Carathers M,Ringel MD,Skipworth RJ,Fearon KC,Hollingsworth MA,Muscarella P,Burghes AH,Rafael-Fortney JA,Guttridge DC. 2005. Dystrophin glycoprotein complex dysfunction: A regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell 8: 421–432. Balthasar N,Dalgaard LT,Lee CE,Yu J,Funahashi H,Williams T,Ferreira M,Tang V,McGovern RA,Kenny CD,Christiansen LM,Edelstein E,Choi B,Boss O,Aschkenasi C,Zhang CY,Mountjoy K,Kishi T,Elmquist JK,Lowell BB. 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123: 493–505. Chen AS,Marsh DJ,Trumbauer ME,Frazier EG,Guan XM,Yu H,Rosenblum CI,Vongs A,Feng Y,Cao L,Metzger JM,Strack AM,Camacho RE,Mellin TN,Nunes CN,Min W,Fisher J,Gopal-Truter S,Maclntyre DE,Chen HY,Van der Ploeg LH. 2000. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26: 97–102. De Jonghe BC,Hayes MR,Bence KK. 2011. Melanocorotin control of energy balance: Evidence from rodent models. Cell Mol Life Sci 68: 2569–2588. Deboer MD,Marks DL. 2006. Cachexia: Lessons from melanocortin antagonism. Trends Endocrinol Metab 17: 199–204. Fearon KC. 2008. Cancer cachexia: Developing multimodal therapy for a multidimensional problem. Eur J Cancer 44: 1124–1132. Garfield AS,Lam DD,Marston OJ,Przydzial MJ,Heisler LK. 2009. Role of central melanocortin pathway in energy homeostasis. Trends Endocrinol Metab 20: 203–215. Huszar D,Lynch CA,Fairchild-Huntress V,Dunmore JH,Fang Q,Berkemeier LR,Gu W,Kesterson RA,Boston BA,Cone RD,Smith FJ,Campfield LA,Burn P,Lee F. 1997. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88: 131–141. Livak KJ,Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(−ΔΔCT) method. Methods 25: 402–408. Muscaritoli M,Anker SD,Argiles J,Aversa Z,Bauer JM,Biolo G,Boirie Y,Bosaeus I,Cederholm T,Costelli P,Fearon KC,Laviano A,Maggio M,RossiFanelli F,Schols A,Sieber CC. 2010. Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics.” Clin Nutr 29: 154–159. Norman K,Pichard C,Lochs H,Pirlich M. 2008. Prognostic impact of disease-related malnutrition. Clin Nutr 27: 5–15. Rousso-Noori L,Knobler H,Levy-Apter E,Kuperman Y,Neufeld-Cohen A,Keshet Y,Akepati VR,Klinghoffer RA,Chen A,Elson A. 2011. Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner. Cell Metab 13: 562–572. Tisdale M. 2009. Mechanisms of cancer cachexia. Physiol Rev 89: 381–410. Xu B,Goulding EH,Zang K,Cepoi D,Cone RD,Jones KR,Tecott LH,Reichardt LF. 2003. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6: 763–742. Yanagihara K,Tanaka H,Takigahira M,Ino Y,Yamaguchi Y,Toge T,Sugano K,Hirohashi S. 2004. Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice. Cancer Sci 95: 575–582. Zimmermann M. 1983. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109–110. Citing Literature Volume66, Issue8August 2012Pages 747-751 ReferencesRelatedInformation
Referência(s)