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A Self‐Replicating Hexadeoxynucleotide

1986; Wiley; Volume: 25; Issue: 10 Linguagem: Inglês

10.1002/anie.198609322

1521-3773

Günter von Kiedrowski,

RNA and protein synthesis mechanisms

Autocatalysis in a nonenzymatic, templete-directed condensation has been demonstrated in a system consisting of three oligonucleotides. A simple form of self-replication occurs, albeit only to a small extent: the template T organizes the building blocks Å and B in such a way that condensation can occur, leading to a second template molecule. Such a nonenzymatic process has long been sought, because it is postulated as a sine qua non for prebiotic evolution in theories on the origin of life.