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Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

1999; Springer Nature; Volume: 18; Issue: 5 Linguagem: Inglês

10.1038/sj.onc.1202416

1476-5594

Jason Cook, Sumathi Krishnan, Subbian Ananth, Stephen F. Sells, Yang Shi, McClellan M. Walther, W. Marston Linehan, Vikas P. Sukhatme, Michael H. Weinstein, Vivek M. Rangnekar,

Renal and related cancers

Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.