Produção Nacional
Revisado por pares
Evaluation of antihyperglycaemic activity of Calotropis procera leaves extract on streptozotocin-induced diabetes in Wistar rats
2013; Springer Science+Business Media; Volume: 23; Issue: 6 Linguagem: Inglês
10.1590/s0102-695x2013000600008
ISSN1981-528X
AutoresMário Correia Lima Neto, Carlos Fernando Brasileiro de Vasconcelos, Valerium N. Thijan, Germana Freire Rocha Caldas, Alice Valença Araújo, João Henrique Costa‐Silva, Elba Lúcia Cavalcanti de Amorim, Fabiano Ferreira, Antônio Fernando Morais de Oliveira, Almir Gonçalves Wanderley,
Tópico(s)Phytochemistry Medicinal Plant Applications
ResumoCalotropis procera (Aiton) W. T. Aiton, Apocynaceae, popularly known as "algodão-de-seda", is a wild African bush, rich in bioactive substances that determine the medicinal potential of this species. Diabetes mellitus is a disease that affects about 10% of the population. This study aimed to evaluate the antihyperglycaemic activity of the hydroalcoholic extract of the leaves of C. procera of occurrence in coast of Pernambuco, Brazil. The hydroalcholic extract of the leaves of C. procera (300 and 600 mg/kg/day), vehicle, insulin (6U, s.c.) or metformin (500 mg/ kg/day) were administered orally to streptozotocin-induced diabetic rats (n = 7/group) for four weeks. Changes in body weight, food and water intake, biochemical markers, fasting glucose levels and oral glucose tolerance test were evaluated. The results showed that the C. procera dried extract (300 and 600 mg/kg) reduced significantly the level of blood glucose throughout the evaluation period and improved metabolic status of the animals and ameliorate the oral tolerance glucose test. The phytochemical screening revealed and quantified the presence of phenolic compounds and flavonoids in a percentage of 29.1 and 2.9%, respectively. Thus, we conclude that the extract of the leaves of C. procera has antihyperglycemic activity.
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