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BIBTEX RIS

Enhanced Production of Farnesol by Candida albicans Treated with Four Azoles

2004; American Society for Microbiology; Volume: 48; Issue: 6 Linguagem: Inglês

10.1128/aac.48.6.2305-2307.2004

ISSN

1098-6596

Autores

Jacob M. Hornby, Kenneth W. Nickerson,

Tópico(s)

Bioactive Compounds and Antitumor Agents

Resumo

ABSTRACT The dimorphic fungus Candida albicans excretes farnesol, which is produced enzymatically from the sterol biosynthetic intermediate farnesyl pyrophosphate. Inhibition of C. albicans by four azole antifungals, fluconazole, ketoconazole, miconazole, and clotrimazole, caused elevated farnesol production (10- to 45-fold). Furthermore, farnesol production occurs in both laboratory strains and clinical isolates (J. M. Hornby et al., Appl. Environ. Microbiol. 67:2982-2992, 2001) of C. albicans .

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