Produção Nacional
Antithyroglobulin antibodies in patients with differentiated thyroid carcinoma: methods of detection, interference with serum thyroglobulin measurement and clinical significance
2004; Editora da Universidade de São Paulo; Volume: 48; Issue: 4 Linguagem: Inglês
10.1590/s0004-27302004000400008
ISSN1677-9487
AutoresPedro Weslley Rosário, Frederico Fernandes Ribeiro Maia, Tales Alvarenga Fagundes, Flávio P.J. Vasconcelos, Ludmilla David Cardoso, Saulo Purisch,
Tópico(s)Neuroendocrine Tumor Research Advances
ResumoAntithyroglobulin antibodies (TgAb) were measured using a chemiluminescent immunoassay (ICMA) and an agglutination test. TgAb laboratory and clinical interference with Tg measurements were assessed. The course of TgAb concentration and disease status were compared during 3 years after initial treatment. The agglutination test failed to detect all titers < 10 IU/mL (ICMA). Interference from TgAb was common at high titers, but even low antibody titers (< 5 IU/mL) were able to interfere with Tg measurement. Cases of distant metastases with undetectable Tg (by IRMA) and those apparently free of disease and without thyroid remnants with Tg> 2 ng/ml (by RIA) were identified among patients with TgAb. The exogenous Tg recovery test was normal (> 80%) by the two methods in 22% of patients with TgAb and confirmed laboratory interference. Absence of reduction in TgAb levels was a marker of persistent disease. In conclusion, TgAb should be determined by immunoassays; interference with Tg measurements occurred mainly but not always at high concentrations, with a normal Tg recovery test not excluding this interference. The behavior of TgAb is related to disease persistence or cure.
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