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Effect of thoracic epidural analgesia on clinical outcomes following transapical transcatheter aortic valve implantation

2012; BMJ; Volume: 98; Issue: 21 Linguagem: Inglês

10.1136/heartjnl-2012-302185

1468-201X

Ignacio J. Amat‐Santos, Éric Dumont, Jacques Villeneuve, D. John Doyle, Michel Rheault, Dominique Lavigne, J M Lemieux, André St-Pierre, Michael Mok, Marina Ureña, Luis Nombela‐Franco, Steven Blackburn, Mathieu Simon, Christine Bourgault, José Luís Carrasco, Philippe Pîbarot, Mélanie Côté, Robert DeLarochellière, David J. Cohen, Josep Rodés‐Cabau,

Antiplatelet Therapy and Cardiovascular Diseases

To determine the impact of perioperative thoracic epidural analgesia (TEA) on acute and late outcomes following transapical transcatheter aortic valve implantation (TA-TAVI).A total of 135 consecutive patients who underwent TA-TAVI were included. All patients received catheter-based pain control, either via TEA (TEA group, n=74) or intercostal local analgesia with a catheter placed at the surgical incision site (non-TEA group, n=61), depending on the preference of the anaesthesiologist responsible for the case.Pain level during early postoperative period (verbal rating scale from 1 to 10), 30-day/in-hospital complications and mortality, and 1-year mortality.There were no differences in baseline or procedural characteristics between groups except for a lower left ventricular ejection fraction in the TEA group. The maximal pain score related to thoracotomy in the postoperative period was higher in the non-TEA group as compared with the TEA group (4 (IQR: 3-5)) vs 2 (IQR: 1-3), p<0.001). Non-TEA was associated with a higher rate of pulmonary complications (p<0.05 for nosocomial pneumonia, reintubation and tracheostomy). The 30-day/in-hospital mortality rate was higher in the non-TEA group (22.9% vs 2.7% in the TEA group, p<0.001). At 1-year follow-up, overall mortality remained higher in the non-TEA group (31.1%) compared with the TEA group (10.8%), p=0.005. Similar periprocedural and late results were obtained in a propensity score-matched analysis that included 100 matched patients. In the multivariable analysis, STS score (p=0.027) and absence of TEA (p=0.039) were independent predictors of increased cumulative late mortality.TEA provided superior analgesia following TA-TAVI, and was associated with a dramatic reduction in periprocedural respiratory complications, and both, short- and long-term mortality. These results highlight the importance of obtaining optimal analgesia following TA-TAVI to improve the results associated with this procedure.