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Saponins from the root of Bupleurum falcatum

1996; Elsevier BV; Volume: 41; Issue: 3 Linguagem: Inglês

10.1016/0031-9422(95)00720-2

1873-3700

Naobumi Ebata, Kaoru Nakajima, Kôji Hayashi, Minoru Okada, Masao Maruno,

Sesquiterpenes and Asteraceae Studies

Three new saponins and nine known saponins were isolated from the dried roots of Bupleurum falcatum. On the basis of chemical and spectral analyses, the structures of new compounds, named 4″-O-acetylsaikosaponin d and hydroxysaikosaponins a and c, were established. In aqueous acidic conditions, saikosaponins a and d were converted into not only known compounds, saikosaponins b1 and b2, but also hydroxysaikosaponins a and d, respectively. Furthermore, quantitative analysis of the decoction of Bupleuri Radix itself by HPLC exhibited that it contained saikosaponins a, c and d, and hydroxysaikosaponins a, c and d.