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Novel Recombinant Norovirus Causing Outbreaks of Gastroenteritis in Santiago, Chile

2006; American Society for Microbiology; Volume: 44; Issue: 6 Linguagem: Inglês

10.1128/jcm.01890-05

1098-660X

Roberto Vidal, Patricia Roessler, Verónica Solari, Jimena Vollaire, Xi Jiang, David O. Matson, Nora Mamaní, Valeria Prado, Miguel L. O’Ryan,

Virus-based gene therapy research

ABSTRACT Capsid and polymerase (RdRp) genes of 13 norovirus outbreak strains from Chile were compared. The genes sequences were discordant for five strains, and recombination was confirmed for two of them by amplification of a 1,360-bp gene segment containing a fragment of both genes. These strains belonged to a novel genogroup by RdRp sequence and to genogroup GII/3 by capsid sequence. Determining the clinical and epidemiological impact of human calicivirus recombination will require future studies.