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Revisão Revisado por pares
BIBTEX RIS

MUTYH-associated polyposis (MAP)

2010; Elsevier BV; Volume: 79; Issue: 1 Linguagem: Inglês

10.1016/j.critrevonc.2010.05.011

ISSN

1879-0461

Autores

Maartje Nielsen, Hans Morreau, Hans F. A. Vasen, Frederik J. Hes,

Tópico(s)

DNA Repair Mechanisms

Resumo

The human mutY homologue (MUTYH) gene is responsible for inheritable polyposis and colorectal cancer. This review discusses the molecular genetic aspects of the MUTYH gene and protein, the clinical impact of mono- and biallelic MUTYH mutations and histological aspects of the MUTYH tumors. Furthermore, the relationship between MUTYH and the mismatch repair genes in colorectal cancer (CRC) families is examined. Finally, the role of other base excision repair genes in polyposis and CRC patients is discussed.

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